2. Signaling Pathways
  3. Immunology/Inflammation
    Vitamin D Related/Nuclear Receptor
  4. Glucocorticoid Receptor

Glucocorticoid Receptor

Glucocorticoid Receptor

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Glucocorticoid Receptor (GR, or GCR) also known as NR3C1 (nuclear receptor subfamily 3, group C, member 1) is the receptor to which cortisol and other glucocorticoids bind. The GR is expressed in almost every cell in the body and regulates genes controlling the development, metabolism, and immune response. When the glucocorticoid receptor binds to glucocorticoids, its primary mechanism of action is the regulation of gene transcription. The unbound receptor resides in the cytosol of the cell. After the receptor is bound to glucocorticoid, the receptor-glucorticoid complex can take either of two paths. The activated GR complex up-regulates the expression of anti-inflammatory proteins in the nucleus or represses the expression of pro-inflammatory proteins in the cytosol by preventing the translocation of other transcription factors from the cytosol into the nucleus. Dexamethasone is an agonist, and RU486 and cyproterone acetate are antagonists of the GR. Also, progesterone and DHEA have antagonist effects on the GR.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-13570BR
    Betamethasone acetate (Standard)
    Betamethasone acetate (Standard) is the analytical standard of Betamethasone acetate. This product is intended for research and analytical applications. Betamethasone acetate is a glucocorticoid corticosteroid. Betamethasone acetate induces fetal lung maturation in preterm sheep.
    Betamethasone acetate (Standard)
  • HY-W740175
    6b-Hydroxy triamcinolone acetonide
    		Control
    6b-Hydroxy triamcinolone acetonide is a metabolite of the synthetic corticosteroid Triamcinolone acetonide (HY-B0636). 6b-Hydroxy triamcinolone acetonide is formed from triamcinolone acetonide by the cytochrome P450 (CYP) isoforms CYP3A4, CYP3A5, and CYP3A7.
    6b-Hydroxy triamcinolone acetonide
  • HY-13681S
    Methylprednisolone acetate-d6
    Methylprednisolone acetate-d6 is the deuterium labeled Methylprednisolone acetate (HY-13681). Methylprednisolone acetate, a prednisolone derivative, is a corticosteroid hormone. Methylprednisolone acetate can relieve pain and swelling that occurs with arthritis and other joint disorders in vivo.
    Methylprednisolone acetate-d<sub>6</sub>
  • HY-137919
    Fluticasone 17β-carboxylic acid
    		Control
    Fluticasone 17β-carboxylic acid is an intermediate in the synthesis of the glucocorticosteroid Fluticasone propionate (HY-B0154).
    Fluticasone 17β-carboxylic acid
  • HY-122213
    RU-25055
    		Antagonist
    RU-25055 is a potent antiglucocorticoid. RU-25055 inhibits early antigen production of the EpsteinBarr virus (EBV) by dexamethasone.
    RU-25055
  • HY-B1087R
    Prednisolone (hemisuccinate) (Standard)
    Prednisolone (hemisuccinate) (Standard) is the analytical standard of Prednisolone (hemisuccinate). This product is intended for research and analytical applications.
    Prednisolone (hemisuccinate) (Standard)
  • HY-B1616R
    Clobetasone butyrate (Standard)
    		Agonist
    Clobetasone butyrate (Standard) is the analytical standard of Clobetasone butyrate. This product is intended for research and analytical applications. Clobetasone butyrate is a synthetic glucocorticoid and has topical anti-inflammatory activity especially in skin. Clobetasone butyrate can be used to relieve corticosteroid-responsive dermatoses, including atopic dermatitis and psoriasis.
    Clobetasone butyrate (Standard)
  • HY-106673R
    Hydrocortisone buteprate (Standard)
    Hydrocortisone buteprate (Standard) is the analytical standard of Hydrocortisone buteprate. This product is intended for research and analytical applications. Hydrocortisone buteprate (Hydrocortisone probutate) is a medium potent, non-halogenated double-ester of hydrocortisone with a favorable benefit/risk ratio for the treatment of inflammatory skin disorders. Hydrocortisone buteprate (Hydrocortisone probutate) is available as a 0.1% cream or ointment formulation.
    Hydrocortisone buteprate (Standard)
  • HY-B0154R
    Fluticasone (propionate) (Standard)
    		Agonist
    Fluticasone (propionate) (Standard) is the analytical standard of Fluticasone (propionate). This product is intended for research and analytical applications. Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective glucocorticoid receptor agonist, with an absolute affinity (KD) of 0.5 nM. Fluticasone propionate shows little or no activity at other steroid receptors. Anti-viral activity.
    Fluticasone (propionate) (Standard)
  • HY-17358R
    Loteprednol Etabonate (Standard)
    		Agonist
    Loteprednol Etabonate (Standard) is the analytical standard of Loteprednol Etabonate. This product is intended for research and analytical applications. Loteprednol etabonate (LE) is an orally active "soft" steroid belonging to a unique class of glucocorticoids. Loteprednol etabonate (LE) exhibits anti-inflammatory activity and has been used in optometry and ophthalmology.
    Loteprednol Etabonate (Standard)
  • HY-B0415R
    Fluocinolone (Acetonide) (Standard)
    		Agonist
    Fluocinolone (Acetonide) (Standard) is the analytical standard of Fluocinolone (Acetonide). This product is intended for research and analytical applications. Fluocinolone is a glucocorticoid glucocorticoid receptor agonist. Fluocinolone is effective in preventing both lipid accumulation and inflammation. Fluocinolone can promote the proliferation of DPCs and has the potential role in repairing injured pulp tissues. Fluocinolone can be used to study the prevention of chemotherapy-induced peripheral neuropathy caused by Paclitaxel (HY-B0015).
    Fluocinolone (Acetonide) (Standard)
  • HY-U00043
    Triamcinolone Benetonide
    		Modulator
    Triamcinolone benetonide is a synthetic glucocorticoid corticosteroid with anti-inflammatory activity.
    Triamcinolone Benetonide
  • HY-13571R
    Betamethasone dipropionate (Standard)
    		Modulator
    Betamethasone dipropionate (Standard) is the analytical standard of Betamethasone dipropionate. This product is intended for research and analytical applications. Betamethasone dipropionate is a glucocorticoid steroid with anti-inflammatory and immunosuppressive abilities.
    Betamethasone dipropionate (Standard)
  • HY-B1829R
    Dexamethasone phosphate (Standard)
    		Agonist
    Dexamethasone phosphate (Standard) is the analytical standard of Dexamethasone phosphate. This product is intended for research and analytical applications. Dexamethasone phosphate (Dexamethasone 21-phosphate) disodium is a biologically inactive compound which undergoes dephosphorylation by intra-erythrocyte enzymes. The active metabolite, Dexamethasone, is then released into the circulation by simple passive diffusion through cell membranes. Dexamethasone phosphate disodium-encapsulated erythrocyte has the potential for steroid-dependent ulcerative colitis research.
    Dexamethasone phosphate (Standard)
  • HY-W701984
    11β-Hydroxyetiocholanolone
    		Control
    11β-Hydroxyetiocholanolone is a metabolite of Hydrocortisone (HY-N0583). Hydrocortisone is a steroid hormone or glucocorticoid secreted by the adrenal cortex.
    11β-Hydroxyetiocholanolone
  • HY-B1265R
    Hydrocortisone 17-valerate (Standard)
    Hydrocortisone 17-valerate (Standard) is the analytical standard of Hydrocortisone 17-valerate. This product is intended for research and analytical applications. Hydrocortisone 17-valerate (Cortisol 17-valerate) is a thiazolidine compound.
    Hydrocortisone 17-valerate (Standard)
  • HY-107961R
    Diflorasone diacetate (Standard)
    Diflorasone diacetate (Standard) is the analytical standard of Diflorasone diacetate. This product is intended for research and analytical applications. Diflorasone diacetate is an anti-inflammatory steroid compound used as locally or topically agent. Diflorasone diacetate is being used for skin disorders to control corticosteroid-responsive dermatoses.
    Diflorasone diacetate (Standard)
  • HY-135061
    20α-Dihydro prednisolone
    		Control
    20α-Dihydro prednisolone is a metabolite of Prednisolone (HY-17463).
    20α-Dihydro prednisolone
  • HY-W740216
    N-Demethyl Mifepristone
    		Antagonist
    N-Demethyl Mifepristone (RU 42633) is an active metabolite of Mifepristone (HY-13683). The affinities of N-Demethyl Mifepristone to the glucocorticoid receptor is 61% compared with 100% for Mifepristone.
    N-Demethyl Mifepristone
  • HY-15234R
    Fluticasone furoate (Standard)
    		Activator
    Fluticasone furoate (Standard) is the analytical standard of Fluticasone furoate. This product is intended for research and analytical applications. Fluticasone furoate is a topical, intranasal, enhanced-affinity synthetic trifluorinated corticosteroid with a Kd of 0.3 nM. Fluticasone furoate has potent anti-inflamatory and anti-asthmatic activity, and low systemic exposure. Fluticasone furoate has the potential for allergic rhinitis treatment.
    Fluticasone furoate (Standard)
Cat. No. Product Name / Synonyms Application Reactivity